The dopamine D2 receptor regulates Akt and GSK-3 via Dvl-3
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چکیده
منابع مشابه
The Akt-GSK-3 signaling cascade in the actions of dopamine.
Drugs that act on dopamine neurotransmission are important tools for the management of multiple neuropsychiatric disorders. Classically, dopamine receptors have been shown to regulate cAMP-PKA (protein kinase A) and Ca(2+) pathways through G-protein-mediated signaling. However, it has become apparent that, in addition to this canonical action, D(2)-class dopamine receptors can function through ...
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Dopamine (DA) neurotransmission is an important modulator of both homeostatic food consumption mediated by the hypothalamus, and reward-related/ hedonic food consumption mediated by the brain reward circuit (Lutter and Nestler, 2009; Schwartz et al., 2000; Wise, 2008). Although there are monogenetic mutations that affect the regulation of body weight, the majority of cases of human obesity appe...
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Several lines of studies on schizophrenia have suggested abnormalities in dopaminergic neurotransmission and dopamine receptor densities. The aim of this study was to evaluate putative alterations of the dopamine D2/3 receptor density in extrastriatal brain regions among drug‐naïve schizophrenic patients compared to healthy subjects, to compare drug‐ induced extrastriatal dopamine D2/3 receptor...
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ژورنال
عنوان ژورنال: The International Journal of Neuropsychopharmacology
سال: 2011
ISSN: 1461-1457,1469-5111
DOI: 10.1017/s146114571100109x